Anne's first novel, A Short Time in Luxembourg, was published in 2004. A Short Time in Luxembourg is a powerful depiction of adult disappointments stemming from youthful decision-making. One reviewer noted:  "Part Elizabeth Berg...part Nora Roberts, Macdonald deftly weaves together these two genres as she follows the trials and turmoil of Dr. Anna Haggarty, a 40-something professor in a Colorado university."

Anne's short stories have appeared in WOW Anthology (Words on Water--Galway, Ireland), Matter: Journal of Literature, Art, & Movement, Dublin Quarterly Review, Blue Earth Review, the Belletriste Review, Rocky Mountain Fiction Writers anthologies and more. Presently, Anne is writing about the 19th Century Anglo-Irish writer, Maria Edgeworth. Maria Edgeworth is most famous for Castle Rackrent. However, her novels and short stories rival the best of Jane Austen, a contemporary.